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MT1's two structural modifications address this limitation directly: Nle4 substitution replaces the oxidation-prone methionine at position 4 with norleucine, a structurally similar but metabolically stable residue

A subgroup analysis was conducted on individuals with a prior diagnosis of DR to assess the risk of disease progression to proliferative diabetic retinopathy (PDR), the development of a vitreous hemorrhage, or new-onset diabetic macular edema (DME)

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