For both therapeutic classes, this increased risk of gallbladder or biliary diseases has been thought to be driven by the inhibition of the secretion of cholecystokinin by GLP-1, leading to impaired gallbladder motility and contractility [64, 65]
High doses of leucine may lead to adverse effects, such as interference with nutrient metabolism or increased ammonia levels, so it is important not to exceed recommended amounts
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doi: 10.1530/EC-23-0005 PMID: 37159343 Pronunciation: kan-a-gli-FLOE-zin Dapagliflozin (Farxiga ) Trade Names: Farxiga (Forxiga in Europe) Drug Class: Anti-diabetic drug, Hypoglycemic, SGLT-2 inhibitor, Gliflozin Pharmacology is similar to canagliflozin, the other SGLT-2 inhibitor in this drug class Mechanism of Action: Hypoglycemic : Inhibits the Na-glucose co-transporter 2 (SGLT-2) in the kidney to reduce glucose reabsorption, resulting in increased urinary glucose excretion, and lower plasma glucose
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