IGF-1 LR3 in Stem Cell Self-Renewal Research Research has established that IGF-1 receptor signalling is necessary for human embryonic stem cell self-renewal, and that IGF-1 LR3 can substitute for native IGF-1 in stem cell cultures with increased potency and stability requiring lower concentrations for equivalent or superior biological effects compared to unmodified IGF-1
Key Research Areas Central melanocortin receptor pharmacology PT-141 is studied for preferential activity at MC3R and MC4R receptors in the CNS
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10.1136/annrheumdis-2014-20691725739830 84 Pan M, Gao H, Long L, et al
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