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For example, we observed that both GLP-1 and its presumed inert metabolite GLP-1(936) showed coronary and mesenteric artery vasodilation, as well as cardioprotection from IRI ex vivo, in isolated tissues from both WT and Glp1r -KO ( Glp1r / ) mice, whereas the nondegradable GLP-1R agonist exenatide did not have these effects in the absence of a functional GLP-1R (4, 21)
However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance
That raises the question: What happens to peoples health after they stop taking these medications
The first thing I tell my patients is that the journey toward weight loss is a marathon, not a sprint, and starting these medications is just one prong of a multi-faceted approach
IRS, insulin receptor substrates
As William Miller, CEO of Villya Pharmaceuticals and inventor of our patented technology (WO 2025/064695 A1), I appreciate the discussion around Lillys groundbreaking work in the GLP-1 space
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