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In addition, folate, which acts to increase an enzyme in the salvage pathway for BH4 (more on this below), was also able to help attenuate the aortic valve calcification.[ref] Cardiomyopathy due to tetrahydrobiopterin deficiency: Deficiency of endothelial BH4 in the heart leads to NOS uncoupling and decreased endothelial production of nitric oxide

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