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Tirzepatide Tirzepatide is a newer medication that works as a dual GIP/GLP-1 receptor agonist, targeting two hormones involved in appetite and blood sugar regulation
Rottenstreich A, Elazary R, Ezra Y, Kleinstern G, Beglaibter N, Elchalal U
Given promise as well as challenges, more research is needed on telehealth and digital interventions for adherence to GLP-1 therapy, long-term weight management, and individual behaviors, health outcomes, quality of life, and satisfaction
doi:10.3390/nu14081549
Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)
GLP-1 RAs may also have utility in non-alcoholic steatohepatitis (NASH)
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