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Enhanced Satiety The treatment increases feelings of fullness, reducing the urge to overeat

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Images were collected in low-dose mode with SerialEM (v4.1 or newer) at a calibrated pixel size of approximately 1 /pixel

Role of alpha-cell GLP-1 production in metabolic dysfunction Alpha-cell GLP-1 production as an adaptive response to metabolic dysfunction Although the in vivo physiological function of intra-islet GLP-1 has been questioned since levels of GLP-1 in the pancreas of healthy mice are considerably low and sometimes undetected (5, 83), metabolic stress has been reported to potently increase alpha-cell-derived GLP-1 and decrease L-cell-derived GLP-1 in rodents and humans (18, 58, 8490)