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10.3892/ol.2017.6053 259 WangK.TanS.-L.LuQ.XuR.CaoJ.WuS.-Q.et al (2018a)

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It is the intake, the dose titration, the cycle structure, the follow-up, and the quality of the compounded product

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Produces a depletion of releasable neuronal monoamine neurotransmitters Similar mechanism as deutetrabenazine (Austedo )

The debenzylated product was precipitated in hexane, dried using a centrifuge and vacuum, dissolved in basic water, and purified by dialysis with a dialysis membrane (molecular weight cut-off 3.5 kDa) against deionized water (DIW) for three days before the lyophilization for removing water and collecting the final product