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10.2337/dc16-1324 39 De VadderF.Kovatcheva-DatcharyP.GoncalvesD.VineraJ.ZitounC.DuchamptA.et al (2014)
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In addition, a double-blind trial examining the cardiovascular efficacy and safety of ertugliflozin in patients with T2DM stratified by ejection fraction, showing that dapagliflozin diminished HHF in patients with or without HFrEF [78]
By influencing appetite, insulin sensitivity, and energy regulation, these therapies helped many patients achieve significant and sustainable weight loss
GLP-1R (glucagon-like peptide-1) Natural GLP-1 lasts only a minute or two before an enzyme inactivates it, so most of its signal stays near the gut
This can reduce fat mass and improve body composition
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