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Furthermore, selection of the best chemical modification approach, such as PEGylation, cholesterol conjugation, or phosphorothioate linkage for aptamers, depends on tumor type, patient characteristics, and therapeutic application has been discussed in general by (138)

doi: 10.1210/endo.137.9.8756584

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Keep an eye out for these tell-tale signs of trouble: Cloudy or Hazy Appearance: If the solution looks milky and doesn't clear up after a reasonable amount of time, you likely have a solubility or aggregation problem

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