In Eli Lilly's Phase 2 clinical trial (published in the New England Journal of Medicine, 2023), 338 adults with obesity or overweight (without diabetes) were treated with retatrutide for 48 weeks
Comprehensive assessment to determine if high-dose therapy is appropriate for your condition and healing goals
This receptor-pathway work is laboratory research only
From the 1,236 patients in the non-GLP1R agonist-exposed cohort, 88 patients were diagnosed with NAION (incidence rate: 1.05 and risk ratio: 4.59)
Measurement Methods Gold Standard: DEXA Scan Most accurate body composition measurement Shows exact muscle mass, bone density, fat mass Recommended every 3-4 months Cost: $50-150 per scan Accessible Options: Bioelectrical Impedance Scale: Less accurate but tracks trends ($30-100 one-time purchase) Progress Photos: Same lighting, same pose, same time of day, monthly Circumference Measurements: Waist, hips, thighs, arms, chest (use measuring tape) Strength Benchmarks: Track weights reps in your training log How Clothes Fit: Looser waist but same shoulder/thigh fit = good sign Red Flags That Suggest Muscle Loss Strength decreasing despite consistent training Losing more than 2-3 lbs per week consistently Feeling weaker or unusually fatigued during workouts Clothes fitting looser everywhere (not just waist) DEXA or BIA showing decreased lean mass If you notice these signs, increase protein intake by 20-30g daily and reassess in 2 weeks
Cranberries and cancer: An update of preclinical studies evaluating the cancer inhibitory potential of cranberry and cranberry derived constituents
