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There are several ways one can develop these patches such as hormonal changes, exposure to UV rays, trauma to skin or medications that can cause sunlight changes.Thyroid disorders or natural ageing could also be the reason behind these patches at times

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The mechanism here is difficult to determine, however presumably stems from an increased production of transcobalamin II (22-24)

Bepecin has an antiulcer effect, which also produces a therapeutic effect on inflammatory bowel disease with no side effects

[1] That makes it a common tool in skin, hair-follicle, and connective-tissue research

It is recommended to use the mask 1 to 2 times per week or according to the skin's needs to maintain brightness and an even tone