J Exp Bot 57:30333042 Navrot N, Collin V, Gualberto J, Gelhaye E, Hirasawa M, Rey P, Knaff DB, Issakidis E, Jacquot JP, Rouhier N (2006) Plant glutathione peroxidases are functional peroxiredoxins distributed in several subcellular compartments and regulated during biotic and abiotic stress
Glutathione is a peptide found in plants and animals
Medical therapy & topicals: tyrosinase inhibitors such as azelaic acid, arbutin, niacinamide, retinol, liquorice root extract, botanicals, cysteamine, & novel blockers
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Liver-related The following symptoms may indicate copper accumulation in the liver: weakness feeling tired weight loss nausea vomiting loss of appetite itching jaundice, or yellowing of the skin edema, or the swelling of legs and abdomen pain or bloating in the abdomen spider angiomas, or visible branch-like blood vessels on the skin muscle cramps Many of these symptoms, such as jaundice and edema, are the same for other conditions like liver and kidney failure
This phenomenon is thought to be due to the inability of cells to restore normal GSH levels or to increased production of reactive oxygen species (ROS), which can damage macromolecules fundamental to cell survival before being deactivated by antioxidant defenses