The triple-hormone mechanism (GLP-1, GIP, and glucagon) means it has a stronger effect on your appetite and digestive system than single or dual-hormone treatments like Wegovy or Mounjaro
GLP-1 is a messenger that: Signals to your brain that youre full Slows down how fast food empties from your stomach Helps regulate blood sugar by stimulating insulin release When this mechanism doesnt work correctly, you may end up feeling hungry all the time, eat more than you want to, and deal with constant thoughts of food
Additionally, presumably due to the high concentration of DPP-4 found on hepatocytes, 4050% of the remaining active GLP-1 is degraded across the liver
As always, individual responses may vary
GLP-1s: A long-term medication
(Diabetes Care, 2022) found that patients prescribed semaglutide for weight management achieved 12.1% average weight loss at 12 months, while those prescribed Contrave achieved 4.8% weight loss over the same period