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The tumor suppressor protein p53 increases the expression of the aspartate/glutamate transporter SLC1A3 and the arginine transporter SLC7A3 upon glutamine depletion, leading to resistance to treatments that deplete extracellular glutamine 114,115

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Our results suggest that the RV protective effects are linked to the restoration of GSK3-Drp1 signalling, a critical pathway governing mitochondrial dynamics [19]

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