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It may result in reduced glycemic control, slower weight loss, or loss of cardiovascular benefits

Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, et al

The protective effect of luteolin on cadmium induced liver intestinal toxicity in chicken by gut-liver axis regulation

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Variants in genes encoding the GLP-1 receptor (GLP1R rs6923761) and other peptide-pathway genes can affect receptor sensitivity and signaling efficiency, which may explain why some patients tolerate semaglutide easily while others experience more pronounced symptoms