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Were excited to share positive 48-week topline results from our IMPACT Phase 2b trial evaluating our investigational glucagon/GLP-1 dual receptor agonist in MASH

Using respiratory chambers and detailed appetite assessments, the researchers found that tesofensine: Reduced 24-hour energy intake by approximately 24% compared to placebo Did not significantly alter resting metabolic rate the weight loss was primarily appetite-driven Reduced hunger ratings and increased satiety throughout the day Decreased fat oxidation acutely, but cumulative energy balance was strongly negative These metabolic data confirmed that tesofensine's primary mechanism of action for weight loss is appetite suppression mediated by enhanced monoamine signaling, rather than metabolic stimulation

Smoking: The nicotine and chemicals in cigarettes and other tobacco products can weaken the lining of your colon

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Once bound, the hormone activates fat-storing enzymes