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Safety, Eligibility, and Provider Guidance: Who Benefits From Each Option Oral semaglutide carries contraindications for severe gastroparesis, personal/family history of medullary thyroid cancer, and multiple endocrine neoplasia type 2

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For GIPR whose ECL1 was loosely compacted by peptide 20, three residues (Y13 P -L14 P -D15 P ) strengthened the peptide-binding interface by forming a hydrogen bond with F127 1.29b and a salt bridge with R289 ECL2 , significantly stronger than that observed in GLP-1R and GCGR