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The peptide was originally identified by Loren Pickart in 1973 in human plasma and has since been characterized in saliva, urine, and tissue

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Although the specific genes and pathways may vary, differential DNA methylation in pediatric under- and overnutrition affect genes regulating similar metabolic processes and result in similar disease outcomes

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doi: 10.1016/j.mce.2015.07.003 40 ClemmensenCFinanBMllerTDDiMarchiRDTschpMHHofmannSM