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J Clin Invest (2012) 122(1):388402.10.1172/JCI42497 38 AoyamaEWatariIPodyma-InoueKAYanagishitaMOnoT

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4

Yazici D, Yapici Eser H, Kiyici S, Sancak S, Sezer H, Uygur M, et al

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Despite the indiscriminate inclusion of RCTs judged satisfactory on mechanistic grounds, without considering the basis for treatment or legitimacy, each report concluded that active treatment reduced pain, especially using the micronutrient combination (39), and that although side-effects in up to 19% were usually mild ( eg headache, nausea, allergy, constipation, diarrhoea), they did cause some patients to withdraw from the trial