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According to Folek, obesity experts arent really sure how topiramate curbs hunger, but they think it works on brain chemicals to restrict the release of glutamate, another neurotransmitter that plays a role in appetite

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Electrophysiological and morphological properties of and motoneurons in the rat trigeminal motor nucleus

This translates to less confidence, lower self-esteem, and an increased likelihood of staying inside

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Chang Y.C., Yu Y.H., Shew J.Y., Lee W.J., Hwang J.J., Chen Y.H., Chen Y.R., Wei P.C., Chuang L.M., Lee W.H