The compound (+)-anthrabenzoxocinone inhibits PI3K/AKT/mTOR signaling, inducing cell cycle arrest, apoptosis and autophagy, while elevating reactive oxygen species (ROS) in NSCLC cells (43)
While our results are consistent with a senolytic effect of GPX4 inhibitors, the effects observed in some of the models, although significant, were modest, and we acknowledge that further investigation is needed to assess a potential translation to the clinic
That doesn't mean the results are unreliable, but it does mean a careful read is required
Various portable ultrasound studies are also available
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N-acetyl-L-cysteine inhibits TGF-beta1-induced profibrotic responses in fibroblasts