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GLP attenuates HSC activation, collagen deposition, and -SMA expression by suppressing TGF-/Smad and TLR4/NF-B signaling, modulating ECMreceptor interactions via downregulation of integrins (e.g., ITGA6, ITGA8), and influencing apoptosis and cell cycle regulators

It says licensed 503A pharmacies remain the legally permitted pathway for compounded GLP-1 medications, and characterizes the current climate as intensified enforcement around licensing, sterility verification and supply chain transparency

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