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Upon intravenous administration, ascorbic acid rapidly increases plasma concentrations, bypassing the limitations of gastrointestinal absorption that restrict oral dosing

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A more recent, larger study confirmed these results, finding that the rate of isotretinoin-induced acne flaring dropped significantly from 30% in those who received isotretinoin alone down to 5% in the group that took isotretinoin plus levocetirizine 2