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Among 79 websites marketing compounded GLP-1s or prescriptions for them, 37% stated or implied that the drugs were FDA-approved

The measures included: Appendicular and trunk fat-free mass (proxy for lean muscle) Whole-body and trunk fat mass Body-fat percentage Waist-to-hip ratio Key Findings The researchers found that for every 1-unit reduction in BMI linked to GLP-1 mimicry: Fat mass decreased by ~7.9 kg Lean mass (muscle) decreased by ~6.4 kg Body-fat percentage dropped by ~4.5% In other words, fat loss exceeded muscle loss in both absolute and relative terms, which supports the use of GLP-1 drugs as a viable treatment for obesity

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This relationship helps explain why investigations of amylin signaling frequently examine receptor subtype activity, downstream signaling pathways, and receptor-specific biological responses