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The semaglutide discontinuation symptoms can be managed much more effectively with a tapering approach

Endocrinology 139 , 31273132 (1998)

When the researchers did this, the mice no longer felt sick

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While both agents struggled with the inherent GI burden typical of GLP-1RAs, efpeglenatides limitations were largely dose-related and within manageable expectations, whereas taspoglutides combination of severe immunogenicity and hypersensitivity reactions rendered it clinically unviable