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Microvascular complications issues like retinopathy (eye damage), nephropathy (kidney damage), and neuropathy (nerve damage) are a common concern in T2DM

FS was calculated by the following formula: (LVEDD-LVESD/LVEDD) 100% 24,25,26

Moreover, canagliflozin hindered the transition from the G1 to S phase in the cell cycle and downregulated the expression levels of key cell cycle regulators, including cyclin D1, cyclin D3, cyclin E1, cyclin E2, and E2F1

While combination therapy was not statistically superior to high-dose monotherapy, it was effective, safe and may offer a reasonable alternative for patients not responding to standard doses

This method allows the compounding pharmacist to work with the patient and the prescriber to customize a medication to meet the patients specific needs