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Although it is often asserted that increasing sedentary behavior is a major cause of the obesity pandemic, this is far from clear, and present evidence does not support this conclusion, the authors wrote

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Tirzepatide's dual GIP/GLP-1 action has shown up to 22% weight loss in brand-name clinical trials

Some patients achieve remission of type 2 diabetes through substantial weight loss and improved metabolic health

Insulin resistancecommon in people carrying excess weightdisrupts normal cholesterol metabolism and accelerates the production of small, dense LDL particles, which are more atherogenic than larger LDL particles