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Lack of systemic metabolic regulation The energy generated from the oxidation of fatty acids needs to be fully dissipated through systemic metabolism throughout the human body

Comparative metabolic effects of GLP-1 vs dual-agonist therapies

The most distinctive side effect is dysesthesia (skin tingling), affecting up to 20.9% of patients at the highest dose

doi: 10.1016/j.cmet.2017.09.021, 91

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New neural pathways were forming