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In 2024, a randomized, double-blinded phase 2 clinical trial published in eClinicalMedicine (Hansen et al.) followed 64 adults at increased fracture risk for 52 weeks on once-weekly semaglutide 1.0 mg versus placebo

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Tissue hypoxia and oxidative stress also can contribute to non-immune mediated tissue injury driven by renal stromal cells, further enhancing interstitial immune cell infiltration and fibrosis to create a viscous cycle3