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This occurs through several potential mechanisms: IGF-1 stimulates collagen synthesis and cartilage matrix expansion Growth signalling in synovial tissue may increase fluid production Systemic effects on sodium and water handling This side effect is typically mild and reversible

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One survey shows about 12% of U.S

Biased agonism: one receptor, different signals Where is the GLP-1 receptor actually found

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Long-term systemic use is concerning for copper balance, as copper deficiency has been linked to neurodegenerative disorders and even excess copper is risky