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Noneither CJC-1295 nor MK-677 suppresses endogenous GH production through negative feedback, so there is no recovery period required for the hypothalamic-pituitary axis to resume normal function

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In Study 1 the mean body weight change was 9.4 kg with semaglutide versus 0.93 kg with placebo at week 104

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Cotadutide is safe with the most common side effects being mild to moderate nausea and vomiting, but with no greater severity or frequency than found in GLP-1 agonists [44]