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Reducing food intake and extending satiety are significant for weight management and loss

GLP-1 receptor agonists, such as semaglutide and liraglutide, are primarily used to manage type 2 diabetes and have been shown to aid in weight loss

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These analogs emulate endogenous GLP-1 by activating GLP-1R, stimulating release of insulin

On the contrary, GLP-1 suppresses glucagon secretion in both healthy individuals and those with T2DM under normoglycemia and hyperglycemia (58) but not during hypoglycemia (131), thereby reducing the potential for developing severe hyperglycemia or hypoglycemia