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Scenario 2 (delayed or limited approval): If cardiovascular safety concerns emerge (glucagon agonism theoretically increases heart rate and may elevate blood pressure in susceptible individuals) or gastrointestinal tolerability limits real-world adherence, retatrutide remains investigational
If amycretin succeeds, it could make cagrilintide as a standalone product less relevant, though the amylin mechanism it pioneered would live on in the new molecule
Many drugs going to the cemetery and being taken off the market, causing side effects and cardiovascular problems that caused them either not to be used or to be taken off the market
Employers are concerned about spending so much money without knowing employees are committed and able to reap the long-term health benefits, Barner said
