SAR work functions as a blueprint for compound design, identifying which structural features drive activity and which can be modified
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Vibert, L., Daulny, A., & Jarriault, S
Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models