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Department leaders think lowering obesity will save the state money in the long run, said Jay Ludlam, deputy secretary for North Carolina Medicaid
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In diabetes and obesity, growth factor-associated signaling in the brain deteriorates and energy use in the cerebral cortex decreases simultaneously with pro-inflammatory changes, while GLP-1RAs improve neuronal growth and repair, reduce inflammation and apoptosis, as well as oxidative stress [31]
they can discuss NICE-approved options such as semaglutide (Wegovy) or tirzepatide (Mounjaro) and advise on clinical trial eligibility for investigational treatments like retatrutide
Further, unlike GLP-1, GIP increases triglyceride storage in white adipose tissue, does not delay gastric emptying, and may impact bone remodeling--functions that were thought to limit GIPs utility in T2D and weight loss
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