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It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years, lead investigator Ania Jastreboff, MD, professor of medicine and pediatrics at the Yale School of Medicine and director of the Yale Obesity Research Center, said in a press release

The article names flank pain, changes in urinary frequency, and cloudy urine as symptoms that should prompt an immediate call to your healthcare provider while on GLP-1 therapy

Stop Taking the Medication (Under Medical Guidance): Do not discontinue any prescribed medication without consulting your doctor

AEs: GLP-1 RAs showed a trend toward an increased risk of AEs across multiple populations

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The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling