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(Elsevier, 2017)

This study matters because we need to understand whether similar skeletal changes occur with HEAOM-associated weight loss so clinicians can help people lose weight safely while protecting long-term bone and musculoskeletal health

The phase 3b STEP UP obesity trial in more than 1,400 patients compared a 7.2mg weekly subcutaneous injection of semaglutide to the standard 2.6mg weekly dose sold as Wegovy or a matched placebo over 72 weeks

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But its American version can only stay 21 days at room temperature

That anomaly implied a distinct receptor system responsive to a new class of GH-releasing peptides