Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors
It can potentially inhibit the entry of thyroid hormone into cells, which might reduce the efficacy of thyroid hormone replacement therapy
Other factors include ER stress, dysregulation of adipokine, and inflammation
Notably, early intervention in the precancerous stage of digestive cancers could significantly reduce the risk of malignant transformation and improve the life quality of patients (Kumari et al., 2022
This makes it a valuable tool in the management of conditions related to excess abdominal fat, such as metabolic syndrome and cardiovascular disease, read more here
Always consult with a healthcare professional before starting any new supplement regimen