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The claudins: from tight junctions to biological systems

Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes

Slow, smaller meals and options such as ginger can greatly alleviate symptoms

Cancers like lymphoma, leukemia, and metastatic cancer are also common culprits

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By inhibiting DPP-4, these drugs prolong incretin activity, leading to: Glucose-dependent insulin secretion from beta cells Suppression of glucagon from alpha cells Improved postprandial blood glucose control This mechanism does not stimulate insulin release in absence of glucose, making hypoglycemia rare