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7 Therapeutic landscape & precision therapeutics 7.1 Established therapeutic pillars and their mechanistic foundations The management of DKD has undergone a substantial transformation with the emergence of four cornerstone pharmacological classes that consistently attenuate renal decline: inhibitors of the renin-angiotensin system (RAS) (Yaribeygi et al., 2021

2C to 8C for short-term use Intended Use: In vitro laboratory research and analytical testing only

Statistical analysis Statistical analysis was performed using parametric two-way mixed model ANOVA (one factor is repeated-measures) and Student Newman-Keuls test to compare the difference between groups

doi:10.3233/JAD-130584 190

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