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Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy

Hormonal Regulation Insulin helps lower homocysteine (Hcy) by turning it into methionine, which reduces cysteine and glutathione (GSH) production

Whilst this may result in less robust therapeutic effects, a tolerable lower dose that patients can maintain long-term often proves more beneficial than a higher dose that leads to discontinuation

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J Leukoc Biol