First, substantial oxidative damage to nucleic acids, lipids, and proteins has been detected in many PD models as well as in the SNc of PD patients 3,4,5
The interaction isnt universal toxicity but pathway interference at concentrations that individual compound safety profiles dont predict
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Remember the observations on the FDA 483 are just the investigators opinions
Glutathione is a compound made up of three amino acids: glutamate, cysteine and glycine
Clinical evaluation included daily assessment of lameness, defined as the inability of the rabbit to bear weight and maintain the typical flexion-extension cycle of the affected limb compared to the unaffected limb