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doi:10.1097/GME.0000000000002060

This study highlights the essential protective role of the type II transmembrane serine protease (TTSP), hepsin, in mitigating acetaminophen-induced liver injury, particularly through its regulation of gap junction (GJ) abundance in response to reactive oxygen stress in the liver

However, researchers reported contrasting results in a study published in Clinical Gastroenterology and Hepatology, in which a nationwide commercial administrative claims database showed that compared with dipeptidyl peptidase 4 inhibitors or chronic opioids, GLP-1 use did not correlate with an increased risk for aspiration pneumonia in patients with type 2 diabetes

thus, the mutant OPTN detected in individuals with ALS is unable to suppress NF-B activity

Amit Rajguru is a board-certified internal medicine specialist

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