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Doseresponse curves were generated at equilibrium (10 min) and EC 50 values were calculated from this

This can affect potency and effectiveness

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Of note, both PIONEER-6 and SUSTAIN-6 were non-inferiority CV safety studies and, thus, not powered to demonstrate superiority

Additional Benefits: Helps regulate mood and sleep via serotonin production Supports immune function Reduces the risk of nerve irritation or neuropathy in diabetics Possible Side Effects: At therapeutic doses, it is very safe