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6.6 Effects on renal functions The result of clinical trials of tirzepatide on kidney function indicates potential renal advantages, especially in individuals with type-2 diabetes (T2D) and a heightened cardiovascular risk.In the SURPASS-4 (NCT03730662) trial, tirzepatide was observed to reduce occurrence of the composite kidney endpoint (like eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new-onset macro albuminuria) in comparison to those receiving insulin glargine

This category of people, non-responders, lost less than 5% of their body weight

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In practice, providers may advise against NAD+ injections in patients with serious underlying medical conditions as a precaution