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Preventing glucose absorption with phloridizin abolishes glucose-stimulated GIP secretion in healthy wild-type (Sykes et al., 1980) and Kir6.2 / mice (Ogata et al., 2014), even in the presence of a -methyl-D-glucopyranoside (Moriya et al., 2009)

For example, insufficient B12 may result in methyl folate not being able to give up its methyl group and it gets stuck in-between the two cycles, with MTR not being able to do its part

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