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GIP receptor activation contributes to insulin secretion, appetite modulation, and potentially beneficial effects on bone and cardiovascular health

206,220,221 Given that endoplasmic reticulum stress, impaired autophagy and proliferation, and increased apoptosis are all suggested to promote islet beta-cell pathology in T2D, and the findings that GLP-1R activation can influence all of these give GLP-1 and its analogues a role beyond just enhancing insulin secretion

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Recovery of LVDP was greater in GLP-1(2836) hearts than in buffer- or scramble-treated hearts (57.6% 6.6%, n = 12 vs

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