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The production of melanin is triggered by an enzyme called tyrosinase

Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients

E., Anderson, P., Storms, D

mitochondria)

1 2 3 4 Annual Review of Pharmacology and Toxicology

Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose)