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Similarly, bariatric procedures such as Roux-en-Y gastric bypass alter the anatomy and mixing of digestive contents, leading to impaired B12 absorption and necessitating lifelong B12 supplementation according to American Society for Metabolic and Bariatric Surgery guidelines

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Nicotinamide mononucleotide, a key NAD + intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice